Attending USCAP and AACR this year? Grab a coffee with our team!
As always, feel free to get in touch if you have any questions or would like to book a demo. You can also check out our Resources page for the latest guides, posters and webinars.
Are you aware of the variability in control materials across pathology labs?
If you are engaged in the field of IHC, you're likely aware of the variability in control materials across labs - differences in batches, fading analyte expression, and inconsistent analyte concentrations. Have you encountered such issues in your lab?
Last January, we invited three experts to explore these challenges:
We’re excited to share our latest Q&A session with OracleBio, a pioneering CRO in quantitative digital pathology, as they discuss their journey with Visiopharm’s software.
Join Gabriel Reines March and Karen McClymont as they share their insights on the impact of our software to enhance research and development in pharma and biotech globally.
“The power and versatility of the software, with the addition of deep learning capabilities, is well-suited to the innovative way OracleBio approaches algorithm development for the multitude of staining profiles that we encounter.”
Great publication showcasing the complete Phenoplex™ workflow for multiplex images on Imaging Mass Cytometry (IMC) data
Congratulations to Soizic Garaud & the LBAI - B Lymphocytes, Autoimmunity and Immunotherapies - Inserm U1227 team at Brest University, for the incredible work developing a spatial analysis pipeline using Phenoplex on IMC data from their Hyperion system (Standard BioTools).
The purpose of the study was to investigate immune infiltration of patient skin samples affected by cutaneous immune-related adverse events (irAEs) due to Immune Checkpoint Inhibitors (ICI), ICI-induced lichen planus, and compare these to control non-drug related lichen planus patient skin samples.
The team employed Phenoplex for tissue and cell segmentation, phenotyping, involving setting thresholds for marker positivity and visual data exploration and QC using the built-in interactive visualization tools. Analysis with Phenoplex results uncovered that ICI-induced lichen planus showed a reduction in T cell infiltration and an increase in B cell frequency, and that these B cells are organized in aggregates close to T cells in the inflamed tissue microenvironment.
Phenoplex was used for: 1) Visualization 2) Tissue Segmentation 3) Nuclear and cell segmentation 4) Cellular phenotyping 5) Results exploration
